Hotel Orfila occupies a small 19th-century palace in Madrid’s Chamberí district, positioned between the center and Salamanca. With only 32 rooms, the hotel feels closer to a private house than a conventional five-star property. It creates a green, surprisingly secluded setting for breakfast, drinks or an unhurried afternoon, and gives the property a sense of space that its intimate urban footprint would not suggest.

Hotel Orfila is a 32-room Relais & Châteaux retreat inside a 19th-century palace, with individually furnished rooms, a secluded garden and one of Madrid’s most residential luxury atmospheres.